Dopamine is a safe antiangiogenic drug which can also prevent 5-fluorouracil induced neutropenia

Dopamine is a safe antiangiogenic drug which can also prevent 5-fluorouracil induced neutropenia.

The role of vascular endothelial growth factor A (VEGFA) in tumor angiogenesis is well established and accordingly, molecules targeting VEGFA or its receptors are being presently used in the clinics for treatment of several types of cancer. However, these antiangiogenic agents are expensive and have serious side effects. Thus identification of newer drugs with manageable systemic side effects o...

5-Fluorouracil in progressive systemic sclerosis: is it safe?

A case of 5-fluorouracil induced encephalopathy.

Patients with reduced dihydropyrimidine dehydrogenase (DPD) activity are at risk for experiencing serious adverse effects following 5-fluorouracil (5-FU) based chemotherapy. Neurotoxicity is considered an extremely rare side effect of 5-FU. We report here on an unusual case of 5-FU induced encephalopathy. A 38-year-old woman with advanced gastric carcinoma was treated with adjuvant chemotherapy...

[5-Fluorouracil-induced reticular hyperpigmentation].

superficial dermis with occasional melanophages (Figure 3). The patient continued to receive cycles of chemotherapy, with no observed increase in pigmentation, until completing the treatment after 11 infusions. Five months after the last cycle of chemotherapy and 8 months after the appearance of the hyperpigmentation, no pigmentation was seen on the palms of the hands, and the reticular pigment...

5-fluorouracil-induced coronary vasospasm.

BACKGROUND Cardiotoxicity is a rare but well-documented adverse effect of 5-fluorouracil (5-FU). The underlying cause of this side effect of 5-FU is uncertain. METHODS We present a case report of a 63-year-old man treated for metastatic colon cancer who experienced chest pain while being treated with the FOLFIRI regimen. This case report documents coronary artery spasm on catheterization obse...